Urolithin A
A gut-derived metabolite of pomegranate polyphenols that's become a longevity favorite for renewing tired mitochondria (a process called mitophagy).
Benefits
- +May promote mitophagy (recycling of damaged mitochondria)
- +May improve muscle strength and endurance in older adults
- +May support cellular energy and healthy aging
- +Antioxidant and anti-inflammatory effects
- +May support muscle recovery
Dosage & Cost
Only about a third of people produce meaningful urolithin A from dietary pomegranate/walnuts, which is why direct supplements (e.g. Mitopure) exist. Trials used 500–1000 mg.
Side Effects
- !Very well tolerated in clinical trials
- !Mild digestive upset possible
- !Limited long-term safety data
- !Direct supplementation is needed because many people's gut bacteria can't produce it from food
Food Sources
- • Pomegranates (precursors)
- • Walnuts
- • Raspberries and strawberries
- • Note: the body must convert these via gut bacteria, which varies widely between people
References & Links
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Featured Videos
Urolithin A Supplement For Mitochondrial Health | Review By Modern Healthspan
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Urolithin A & Its Health Benefits | Dr Anurag Singh Interview Series Ep 1
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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.