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Spermidine

A naturally occurring polyamine that declines with age — it's one of the most exciting compounds in longevity research because it triggers autophagy, your body's cellular cleanup process.

Benefits

  • +Triggers autophagy — your cells' recycling and repair mechanism
  • +May support cardiovascular health and longevity
  • +Emerging evidence for improved cognitive function with age
  • +May support healthy cell renewal
  • +Levels naturally decline with age — supplementation aims to restore youthful levels

Dosage & Cost

Range1–3 mg/day
TimingAny time of day, with or without food
Daily cost0.50–2.00

This is a very small dose — mg, not grams. Wheat germ is the richest natural source. Research is promising but still in early stages — manage expectations.

Side Effects

  • !Generally well-tolerated at studied doses
  • !May cause mild digestive upset or nausea in some people
  • !Research is still relatively early — long-term effects not fully characterized
  • !May interact with certain medications (consult your doctor if on cancer treatment)

Food Sources

  • Wheat germ (richest source)
  • Aged cheese
  • Mushrooms
  • Soybeans
  • Legumes
  • Green peas

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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.