SAMe (S-Adenosyl-L-Methionine)
Your body's most important methyl donor — SAMe is involved in over 100 chemical reactions, from mood regulation to joint cartilage repair.
Benefits
- +May help with mild-to-moderate depression (FDA-approved in Europe for this use)
- +Supports healthy joint cartilage and may reduce osteoarthritis pain
- +Important for liver health and detoxification
- +Involved in neurotransmitter production (serotonin, dopamine)
- +May support healthy methylation throughout the body
Dosage & Cost
SAMe is unstable — always buy enteric-coated (EC) formulations stored in blister packs. Start low (200 mg) and increase gradually. Talk to your doctor, especially if you have a mood disorder.
Side Effects
- !Can cause anxiety, restlessness, or insomnia
- !May trigger mania in people with bipolar disorder — AVOID if you have bipolar
- !Can cause digestive upset, headaches, or dry mouth
- !May increase blood pressure
- !Should be used with care alongside antidepressants (serotonin syndrome risk)
Food Sources
- • SAMe is produced internally from methionine and ATP
- • Not available in meaningful amounts from food — supplementation is the only way to significantly increase levels
References & Links
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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.