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NR (Nicotinamide Riboside)

Another way to boost NAD+ — this vitamin B3 derivative has a solid body of research behind it and is one of the better-studied longevity supplements available.

Benefits

  • +Raises NAD+ levels in the blood (well-documented)
  • +May support energy, metabolism, and healthy aging
  • +Some evidence for improved insulin sensitivity
  • +May support cognitive function as NAD+ declines with age
  • +Has more long-term clinical trial data than NMN
  • +May support mitochondrial health

Dosage & Cost

Range250–500 mg/day
TimingMorning
Daily cost$0.80–$2.50

NR and NMN are both NAD+ precursors and do similar things — you don't need both. NR has slightly more clinical trial data. Tru Niagen is the most studied branded form. Taking both NR and niacin together isn't necessary.

Side Effects

  • !Generally well tolerated
  • !Possible digestive upset
  • !May lower blood sugar slightly
  • !Flushing (less common than niacin, but possible)
  • !Headache in some users

Food Sources

  • Milk (especially cow's milk)
  • Cheese
  • Mushrooms
  • Green vegetables
  • Note: amounts in food are very small — supplementation is the practical route

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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.