NAD+ (Nicotinamide Adenine Dinucleotide)
A coenzyme critical to energy production and DNA repair that declines significantly with age — replenishing it is one of the hottest ideas in longevity science.
Benefits
- +Plays a central role in cellular energy metabolism
- +Supports DNA repair pathways
- +Declines with age — replenishing may support healthy aging
- +May support brain function and cognitive clarity
- +Important for sirtuins — proteins linked to longevity
Dosage & Cost
Direct NAD+ supplementation has bioavailability questions. NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are more commonly used precursors. This is an active research area — stay tuned for more data.
Side Effects
- !Can cause flushing (especially niacin-related forms)
- !Headaches in some people
- !May disrupt sleep if taken too late in the day
- !Expensive — and precursors (NMN, NR) may be more cost-effective and better absorbed
Food Sources
- • NAD+ is found in small amounts in many foods but rapidly breaks down
- • Milk, eggs, fish, and mushrooms contain modest NAD+ precursors
- • Supplementation is the only way to meaningfully raise NAD+ levels
References & Links
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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.