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Citicoline (CDP-Choline)

A brain-friendly form of choline that crosses the blood-brain barrier easily — it's both a choline source and a phospholipid builder, making it a top-tier cognitive supplement.

Benefits

  • +Supports brain health and cognitive function
  • +Provides choline and cytidine — both important for brain phospholipid synthesis
  • +May protect against cognitive decline
  • +Supports healthy dopamine and norepinephrine signaling
  • +Well-studied for neuroprotection, especially post-stroke

Dosage & Cost

Range250–500 mg/day
TimingMorning
Daily cost0.20–0.60

Citicoline is considered the premium choline source for brain health — better than choline bitartrate for cognitive effects. Often paired with racetam nootropics or taken solo as a foundational brain supplement.

Side Effects

  • !Very well tolerated
  • !Rare: mild headaches or nausea
  • !May cause insomnia if taken too late in the day
  • !Generally one of the safest nootropics available

Food Sources

  • Egg yolks are the richest common source of choline (the base compound)
  • Liver
  • Broccoli
  • Brussels sprouts
  • CDP-choline itself is not a dietary food — it's synthesized for supplementation

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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.