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L-Lysine
An essential amino acid best known for helping manage cold sores, while also supporting collagen, calcium absorption, and immune health.
Benefits
- +May reduce frequency and severity of cold sore (herpes simplex) outbreaks
- +Essential for collagen formation and tissue repair
- +Supports calcium absorption and bone health
- +Supports immune function
- +May help with stress and anxiety response
Dosage & Cost
Range1000–3000 mg/day
TimingOn an empty stomach for best absorption; higher doses used during cold sore outbreaks
Daily cost$0.05–$0.15
For cold sore prevention, 1 g/day is common; up to 3 g/day during active outbreaks.
Side Effects
- !Generally well tolerated
- !Digestive upset or diarrhea at high doses
- !Abdominal cramps
- !Caution advised in people with kidney disease
Food Sources
- • Meat (beef, chicken, pork)
- • Fish
- • Eggs
- • Dairy (cheese, yogurt)
- • Legumes (soy, lentils)
References & Links
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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.