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Diosmin + Hesperidin

A duo of flavonoids (often sold together as Daflon or similar brands) that strengthen and protect your blood vessel walls — the go-to supplement for varicose veins and vein health.

Benefits

  • +Strengthens blood vessel walls and capillaries
  • +May significantly reduce varicose vein symptoms (heaviness, aches, swelling)
  • +Supports healthy venous circulation
  • +May help with hemorrhoids
  • +Anti-inflammatory effects on the vascular system
  • +Well-studied in clinical trials — strong evidence base

Dosage & Cost

RangeDiosmin 450 mg + Hesperidin 50 mg once daily (the classic Daflon ratio), or up to 1000 mg total for acute symptoms
TimingOnce or twice daily, with meals
Daily cost0.15–0.50

The Diosmin 450 / Hesperidin 50 combination (known as Daflon 500) is the most-studied formulation. Prescription in some countries, OTC supplement in others.

Side Effects

  • !Generally very well-tolerated
  • !Can cause mild digestive upset or headache
  • !May interact with blood-thinning medications
  • !Rare: allergic reactions

Food Sources

  • Hesperidin is found in citrus fruits (especially peels)
  • Diosmin is semi-synthetic — not naturally abundant in foods
  • Citrus flavonoids in general support vein health

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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.