Collagen Type II (Undenatured)
A specific type of collagen found in cartilage — the 'undenatured' form works through a unique immune mechanism to calm joint inflammation rather than just providing building blocks.
Benefits
- +May reduce joint pain and inflammation in osteoarthritis
- +Works via oral tolerance — teaches the immune system to stop attacking cartilage
- +Very low dose needed (10–40 mg/day) compared to hydrolyzed collagen
- +May support healthy cartilage preservation
- +Some evidence for rheumatoid arthritis support
Dosage & Cost
This is NOT the same as hydrolyzed collagen (Types I & III). The mechanism is different — oral tolerance. Much smaller doses are effective. Look for 'undenatured' or 'native' on the label.
Side Effects
- !Generally very well-tolerated
- !Rare: mild digestive upset
- !May not be suitable for people with severe autoimmune conditions without medical guidance
Food Sources
- • Chicken cartilage (especially the joints and skin)
- • Bone broth made with joints/cartilage
- • Not widely available in standard foods — supplements are the main source
References & Links
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This page is for informational purposes only. The information here has not been evaluated by the Food and Drug Administration (FDA). No supplement discussed on this page is intended to diagnose, treat, cure, or prevent any disease. Please consult your doctor or a qualified healthcare professional before taking any dietary supplement.